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KMID : 1031120170070020106
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Journal of Epilepsy Research
2017 Volume.7 No. 2 p.106 ~ p.108
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Levetiracetam-Induced Skin Hyperpigmentation: An Extremely Rare Undesirable Side Effect
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Algahtani Hussein
Marghalani Siham
Satti Mohamed
Shirah Bader Hamza
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Abstract
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Levetiracetam is one of the newer second-generation antiepileptic drugs with multiple mechanisms of action. Cutaneous side effects due to levetiracetam are rarely reported in the literature. In this article, we describe a patient with skin hyperpigmentation due to the treatment with levetiracetam with complete resolution after discontinuation of the medication. In addition, we review the topic and hypothesize the mechanism behind this rare complication. To the best of our knowledge, this is the first report of skin hyperpigmentation as a side effect of levetiracetam in the literature. The prescribing physicians should inform the patients about all potential side effect of levetiracetam including skin hyperpigmentation. Similar to many undiagnosed conditions, increased awareness of their existence is the key to diagnosis. Early recognition and timely cessation of therapy are important to reverse this effect. Further studies should be conducted to explore the pathophysiology of this rare side effect.
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KEYWORD
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Levetiracetam, Skin hyperpigmentation, Adverse effect, Drug-induced
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